Prevnar 13 Pneumococcal Vaccine News For 2019
– The UK Health Agency published the 2022 complete immunization schedule. This schedule recommends children at 12 weeks receive Prevnar 13.
– The U.S. CDC published new immunizations schedules for both Children and Adults.
– Pfizer Inc. reported Prevnar / Prevenar 13 & 20 global sales decreased 25% operationally, driven by a 27% decline in the U.S. primarily due to unfavorable timing of government purchases for the pediatric indication and disruptions to healthcare activity related to COVID-19, and a 24% operational decline outside the U.S. primarily due to the impact of increased adult uptake in the prior-year period from greater vaccine awareness for respiratory illnesses.
– World Pneumonia Day, November 12, 2021, will address the future of pneumonia prevention.
– Pfizer reported financial results. Prevnar 13 was up 34% in the USA, driven by 35% growth in the pediatric indication primarily due to higher levels of healthcare activity and wellness visits compared to the prior-year quarter, which was heavily impacted by COVID-19-related mobility restrictions and limitations, and favorable timing of government purchases, partially offset by a lower year-over-year birth rate, and 24% growth in the adult indication, which was primarily driven by higher levels of healthcare activity compared to the prior-year quarter, partially offset by the impact of a lower remaining eligible unvaccinated population.
Prevnar 13 Pneumococcal Vaccine Indication
Pneumococcal disease refers to any illness caused by pneumococcal bacteria. These bacteria can cause many types of illnesses, including pneumonia, an infection of the lungs. Pneumococcal bacteria are one of the most common causes of pneumonia, says the U.S. CDC.
Prevnar 13 is a vaccine indicated in children 6 weeks through 17 years for active immunization for the prevention of invasive disease caused by Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F. In addition, for children 6 weeks through 5 years of age to prevent otitis media caused by 7 of the 13 serotypes in the vaccine.
In 2014, the ACIP recommended that older adults receive the 13-valent pneumococcal conjugate vaccine first, then the PPSV23 at least 1 year later. Since then, widespread childhood vaccination with PCV13 and its predecessor, the 7-valent pneumococcal conjugate vaccine, have led to sharp declines in pneumococcal disease among unvaccinated children and adults, according to the ACIPs review of the evidence.
Additionally, on February 18, 2022, ACIP voted to remove PCV13 from the list of recommended vaccines for adults. The new recommendation now states that adults 65 years and adults 18-64 with certain medical conditions who have not previously received a pneumococcal conjugate vaccine or whose previous vaccination history is unknown should receive 1 dose of PCV15 or 1 dose of PCV20. If PCV15 is used, this should be followed by a dose of PPSV23.
Pneumococcal Vaccinations And Flu Shots
Whats the correct way to code pneumococcal vaccinations and flu shots given by a nurse?
The answer depends on several factors. My answer assumes that this is the only service provided and that there is no evaluation and management component involved.
The CPT codes for the pneumococcal vaccine are 90669 and 90732. There are four codes for flu vaccine: 90657, 90658, 90659 and 90660. The appropriate vaccine administration code should also be reported. There are two administration codes to be used for most non-Medicare patients: 90471 for administering one vaccine and 90472 for administering each additional vaccine. So, for example, if a patient received both the flu and pneumococcal vaccines at the same encounter, the practice would code the two vaccines plus 90471 and 90472.
Medicare has different codes for vaccine administration, so for Medicare patients the practice should use G0008, Administration of influenza virus vaccine, and G0009, Administration of pneumococcal vaccine, in addition to the appropriate codes for the vaccines themselves.
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How To Bill For Covid
Proper medical billing for the Coronavirus vaccine is important for not only reimbursement but governmental reporting purposes.
Each Coronavirus vaccine has its own specific CPT code based on the vaccine manufacturer . The vaccine administration code is also based on the manufacturer plus the number of doses.
If you receive the COVID-19 Vaccine form the government to administer to patients, remember to only bill the vaccine administration codes when submitting claims. DO NOT include the vaccine CPT codes when the Coronavirus vaccines are free.
Prevnar 20 Vaccine Indication

The U.S. CDC recommends pneumococcal vaccination for children younger than two years old and adults 65 years or older. In addition, in certain situations, older children and other adults should also get pneumococcal vaccines. Globally, pneumococcal pneumonia is estimated to cause about 500,000 deaths and 30 million episodes in adults 70 years and older annually. Together, the 20 serotypes included in 20vPnC are responsible for the most currently circulating pneumococcal disease in the U.S. and globally, says the CDC.
The PREVNAR 20 is a 20-Valent pneumococcal conjugate vaccine candidate to prevent invasive disease and pneumonia caused by Streptococcus pneumoniae serotypes in adults aged 18 and older. The seven new serotypes included in 20vPnC are global causes of invasive pneumococcal disease and are associated with high case-fatality rates, antibiotic resistance, and/or meningitis.
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Cms Updated Payment And Hcpcs Level 1 Cpt Code Structure
There is an updated payment and code structure that has been put out by CMS that has specific COVID-19 vaccine information.
Here is the link to the update:
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Have you added these codes to your EHR and medical billing software? Leave a comment below.
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Adults Aged 65 Years And Older
A randomized placebo-controlled trial of 13-valent pneumococcal conjugate vaccine was conducted in about 84,500 adults aged 65 years and older, with no particular risk factors. Four years on average after vaccination, there was no reduction in either mortality or the overall incidence of community-acquired pneumonia. It was necessary to vaccinate about 1,000 individuals in order to prevent 1 case of vaccine-type pneumococcal pneumonia during the 4-year follow-up period .
In 2019, the Centers for Disease Control and Prevention updated the recommendations of the Advisory Committee on Immunization Practices for use of 13-valent pneumococcal conjugate vaccine . PCV13 vaccination is no longer routinely recommended for all adults aged 65 years and older. Instead, shared clinical decision-making for PCV13 use is recommended for persons in this age group who do not have an immunocompromising condition, CSF leak, or cochlear implant and who have not previously received PCV13. If a decision to administer PCV13 is made, it should be administered before PPSV23. The recommended intervals between pneumococcal vaccines remain unchanged for adults without an immunocompromising condition, CSF leak, or cochlear implant . PCV13 and PPSV23 should not be co-administered. ACIP continues to recommend PCV13 in series with PPSV23 for adults aged 19 years with immunocompromising conditions, CSF leaks, or cochlear implants .
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Clinical Trials Experience With Prevnar 13 In Children 6 Weeks Through 17 Years Of Age
The safety of Prevnar 13 was evaluated in 13 clinical trials in which 4,729 infants and toddlers received at least one dose of Prevnar 13 and 2,760 infants and toddlers received at least one dose of Prevnar active control. Safety data for the first three doses are available for all 13 infant studies dose 4 data are available for 10 studies and data for the 6-month follow-up are available for 7 studies. The vaccination schedule and concomitant vaccinations used in these infant trials were consistent with country-specific recommendations and local clinical practice. There were no substantive differences in demographic characteristics between the vaccine groups. By race, 84.0% of subjects were White, 6.0% were Black or African-American, 5.8% were Asian and 3.8% were of ‘Other’ race . Overall, 52.3% of subjects were male infants.
Serious Adverse Events in All Infant and Toddler Clinical Studies
The most commonly reported serious adverse events were in the ‘Infections and infestations’ system organ class including bronchiolitis , gastroenteritis, , and pneumonia for Prevnar 13 and Prevnar respectively.
There were 3 deaths among Prevnar 13 recipients, and 1 death in Prevnar recipients, all as a result of sudden infant death syndrome . These SIDS rates are consistent with published age specific background rates of SIDS from the year 2000.
Solicited Adverse Reactions in the Three US Infant and Toddler Studies
45.3 | 40.3 |
20.4 | 6.8 |
14.8 |
1.4 |
Influenza And Pneumonia Billing
Medicare covers both the costs of the vaccine and its administration by recognized providers. There is no coinsurance or co-payment applied to this benefit and a beneficiary does not have to meet his or her deductible to receive it. Assignment must be accepted on all vaccine claims and a physician order is not required.
Influenza and pneumonia vaccinations and administration are covered under Part B, not Part D.
If a physician sees a beneficiary for the sole purpose of administering one of these vaccines, an office visit cannot be billed. However, if the beneficiary receives other services which constitute an office visit, then one can be billed.
If both vaccines are administered on the same day, providers are entitled to receive payment for both administration fees.
The diagnosis code used for these vaccines and administration is Z23 .
On this page, view the below information:
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Prevention Of Acute Exacerbations Of Copd In Persons With Moderate Severe Or Very Severe Copd
The American College of Chest Physicians and Canadian Thoracic Society guideline on “Prevention of acute exacerbations of COPD” states that in patients with COPD, the panel suggests administering the 23-valent pneumococcal vaccine as part of overall medical management but did not find sufficient evidence that pneumococcal vaccination prevents acute exacerbations of COPD .
Code Code Description
Heptavalent Pneumococcal Conjugate Vaccine
A 7-valent pneumococcal conjugate vaccine has been introduced by Wyeth Lederle for use in children. The FDA has approved of this protein-polysaccharide conjugate vaccine for prevention of invasive pneumococcal disease in infants and toddlers.
The American Academy of Pediatrics and the CDC’s ACIP recommended pneumococcal polyvalent vaccine for routine use in all children 2 and under, and for black, Alaskan Native, and Native American toddlers up to age 5, as well as for those with sickle-cell anemia, HIV infection, or other immunodeficiency diseases. For infants, the AAP and ACIP recommends that the vaccine be given in 4 doses at 2, 4, 6, and 12 to 15 months for children who are 7 to 11 months, 3 doses for children who are 12 to 23 months, 2 doses and for children 2 years or older, only 1 dose is needed. See table below.
Age range | |
---|---|
24 to 59 | 1 |
Pneumococcus is the most frequent cause of otitis media, pneumonia, and bacteremia in children, as well as the principle cause of childhood bacterial meningitis. The most susceptible to pneumococcal diseases are children less than 2 years old. Standard pneumococcal polysaccharide vaccines are poorly immunogenic in this age group. The new protein-polysaccharide conjugate vaccine is immunogenic during infancy and is capable of providing long-term immunity.
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Vii Surveillance And Research Priorities
The epidemiology of invasive pneumococcal disease is changing in Canada and elsewhere, both due to and independent of the use of pneumococcal vaccines. Ongoing changes are expected as PNEU-C-13 vaccines are used routinely in childhood vaccination programs. Nationwide surveillance systems to detect these changes over time are essential. Optimal decisions about the use of pneumococcal vaccines requires ongoing surveillance for serotype-specific rates of invasive pneumococcal disease, and other disease syndromes, serotype-specific estimates of the efficacy of different vaccines, and continuing assessment of the effectiveness and cost-effectiveness of different vaccination schedules over time.
Surveillance and research which addresses the following outstanding questions is particularly encouraged:
The National Vaccine Injury Compensation Program

The National Vaccine Injury Compensation Program is a federal program that was created to compensate people who may have been injured by certain vaccines. Claims regarding alleged injury or death due to vaccination have a time limit for filing, which may be as short as two years. Visit the VICP website at or call to learn about the program and about filing a claim.
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Clinical Trials Experience With Prevnar 13 In Adults 18 Years Of Age
The safety of Prevnar 13 was assessed in 7 clinical studies 612 conducted in the US and Europe which included 91,593 adults ranging in age from 18 through 101 years.
The 48,806 Prevnar 13 recipients included 899 adults who were aged 18 through 49 years, 2,616 adults who were aged 50 through 64 years, 45,291 adults aged 65 years and older. Of the 48,806 Prevnar 13 recipients, 46,890 adults had not previously received Pneumovax® 23 and 1,916 adults were previously vaccinated with PPSV23 at least 3 years prior to enrollment.
Safety and Immunogenicity Studies
Safety and immunogenicity of Prevnar 13 is supported by 6 clinical studies. Study 66 evaluated the safety and immunogenicity of Prevnar 13 in adults 18 through 64 years of age who had not received a previous dose of pneumococcal vaccine. Adults 18 through 59 years of age received a single dose of Prevnar 13, and adults 60 through 64 years of age received a single dose of Prevnar 13 or PPSV23.
Study 7 was randomized and compared the safety and immunogenicity of Prevnar 13 with PPSV23 as a single dose in adults 70 years vaccinated with PPSV23 .7 Study 8 was randomized and evaluated the safety and immunogenicity of Prevnar 13 and PPSV23 in different sequential order in PPSV23 naive adults aged 60 through 64 years8.
Efficacy Study
Serious Adverse Events in Adult Clinical Studies
Safety and Immunogenicity Studies
Efficacy Study
Solicited Adverse Reactions in Adult Clinical Studies
16.5 | 9.7 |
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Prevnar 20 Vaccine Description For 2022
Pfizer’s PREVNAR 20 is a 20-Valent pneumococcal conjugate vaccine that protects adults from a substantial invasive pneumococcal disease and pneumonia burden. PREVNAR 20 includes the 13 serotypes contained in Prevnar 13 plus seven additional serotypes .
Pfizer’s PREVNAR 20 also contains capsular polysaccharide conjugates for seven additional serotypes that cause pneumococcal disease,2,3,4,5,6 and have been associated with high case-fatality rates,7,8,9,10 antibiotic resistance,5,11,12 and/or meningitis.13,14 Together, the 20 serotypes included in 20vPnC are responsible for most currently circulating pneumococcal disease globally.15,16,17,18,19,20,21
On May 14, 2020, Pfizer announced a phase 3 study that found 20vPnC’s safety profile was similar to the Prevnar 13. On Dec. 8, 2020, Pfizer announced that the U.S. FDA accepted for priority review a Biologics License Application for its 20vPnC vaccine candidate, as submitted for the prevention of invasive disease and pneumonia caused by Streptococcus pneumoniae serotypes in the vaccine in adults ages 18 years and older.
On June 8, 2021, Pfizer confirmed the U.S. FDA Approved PREVNAR 20 for the prevention of invasive disease and pneumonia caused by the 20 Streptococcus pneumoniae serotypes in the vaccine in adults ages 18 years and older. In addition, the European Medicines Agency issued its Approval for the brand name Apexxnar on Feb. 15, 2022.
For more information, please visit pfizer.com.
Prevnar 13 Pneumococcal Vaccine Description For 2022
Pfizer Inc.’s Prevnar 13 is a sterile suspension of saccharides of the capsular antigens of Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F, individually linked to non-toxic diphtheria CRM197 protein.
PCV13 protects against 13 of the approximately 90 types of pneumococcal bacteria that can cause the most serious types of pneumococcal disease, including pneumonia, meningitis, and bacteremia. However, Prevnar 13 does not protect against diseases caused by S. pneumoniae serotypes that are not in the vaccine.
The U.S. FDA issued its approval for Prevnar 13 in 2010. In July 2016, the FDA expanded the age indication to include adults 18 through 49 years of age, in addition to the already approved indication for adults 50 years and older.
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