2 Different Types Of Pneumonia Vaccine

Types Of Pneumonia Vaccine

There are two vaccines which can provide protection against Streptococcus pneumoniae. They cannot prevent other types of bacterial pneumonia or any associated with a fungus or virus.

The two FDA-approved vaccines immunize a person against the specific serotypes that are most likely to cause illness and invasive disease. They are:

• PCV13, marketed under the name Prevnar 13,which prevents 13 of the most severe types of S. pneumoniae
• PPSV23, marketed under the name Pneumovax 23, which protects against an additional 23 S. pneumoniae serotypes

Neither vaccine is made from a live or whole bacteria but rather parts of the bacterial shell. While these components cannot cause disease, the immune system recognizes them as threats and triggers a defensive response in the same way it would to a real bacteria.

The PVC13 vaccine is delivered intramuscularly either into the deltoid muscle of the upper arm or the vastus lateralis muscle of the external thigh. The PPSV23 shot can either be given intramuscularly or subcutaneously .

How Does It Work

Prevnar 20 is a conjugate vaccine. This means that it contains pieces of sugar-like substances called polysaccharides that typically coat the bacteria but also hide it from our immune system. The vaccine uses only a certain portion of the bacteria not the bacteria itself so its unable to cause an infection.

This conjugate vaccine uses 20 slightly different polysaccharides that are specific to the 20 serotypes and attaches them to proteins that our immune systems can recognize. If the bacteria enters the body after the vaccination is administered, the immune system can recognize the polysaccharide molecule and release antibodies to fight the bacteria before it causes an infection.

Interaction With Haemophilus Influenzae

Historically, has been a significant cause of infection, and both H. influenzae and S. pneumoniae can be found in the human upper respiratory system. A study of competition revealed S. pneumoniae overpowered H. influenzae by attacking it with . However, in a study adding both bacteria to the of a within two weeks, only H. influenzae survives further analysis showed that neutrophils exposed to dead H. influenzae were more aggressive in attacking S. pneumoniae.

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Why Is Pneumococcal Vaccine Important

Pneumococcal vaccine can prevent pneumonia and other infections caused by 23 types of the Streptococcus pneumoniae bacteria. These 23 types account for approximately nine out of 10 cases of pneumococcal disease. The vaccine is recommended for people with certain medical conditions listed below, and people 65 years of age and older. About eight out of 10 cases occur in these high- risk groups. The vaccine protects about 50 to 80 per cent of people against pneumococcal infection. Vaccination also makes the disease milder for those who may catch it. This pneumococcal vaccine has been used in Canada since 1983.

Who Should Get Prevnar 13 And Pneumovax 23

Prevnar 13 was developed for infants and children. The CDC recommends that all infants and children younger than 2 years of age get Prevnar 13. Prevnar 13 involves a series of four doses of the vaccine given at 2 months, 4 months, 6 months, and sometime between 12 and 15 months of age.

Pneumovax 23 is the vaccine used in adults. It does not work in infants and children under 2 years old.

Most adults do not need a pneumococcal vaccine until they reach the age of 65. Once a person turns 65 years old, the CDC recommends Pneumovax 23.

The same is true for any adult who smokes or has one or more of these chronic illnesses:

• Chronic heart disease

• Chronic lung disease, including asthma and chronic obstructive pulmonary disease

• Diabetes

• Chronic liver disease

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Immunization : Pneumococcal Polysaccharide Vaccine

Vaccines or needles are the best way to protect against some very serious infections. The National Advisory Committee on Immunization strongly recommends routine immunization.

This vaccine protects adults and children two years of age and older against pneumococcal infections like pneumonia. This type of vaccine is only effective in people two years of age and older, and should not be given to children under two years of age. A different type of pneumococcal vaccine is effective in children under two years of age. This fact sheet refers to the “polysaccharide” vaccine only.

The Best Place To Get The Pneumonia Vaccine

If after months of limiting your outings to minimize exposure to COVID-19, the idea of heading to a doctor or pharmacy to get a pneumonia vaccine seems scary, know this: The CDC has outlined safe vaccination practices for local pharmacies, grocery stores, and doctors offices, including:

• Screening for COVID-10 symptoms

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Who Should Not Have The Vaccine

The pneumococcal vaccine used between 1978 and 1983 protected against only 14 types of the pneumococcus. People who received this vaccine do not usually need to get another shot.

• If you think you have already been vaccinated for pneumococcal disease, let your doctor know.
• The polysaccharide pneumococcal vaccine is not recommended for children under two years of age.
• You should not have the vaccine if you have a severe allergy to any component of the vaccine.

Summary Of Information Contained In This Naci Statement

The following highlights key information for immunization providers. Please refer to the remainder of the Statement for details.

1. What

Streptococcus pneumoniae is a bacterium that can cause many types of diseases including invasive pneumococcal disease , and community-acquired pneumonia .

For the prevention of diseases caused by S. pneumoniae in adults, two types of vaccines are available in Canada: pneumococcal 23-valent polysaccharide vaccine containing 23 pneumococcal serotypes and pneumococcal 13-valent conjugate vaccine containing 13 pneumococcal serotypes.

NACI has been tasked with providing a recommendation from a public health perspective on the use of pneumococcal vaccines in adults who are 65 years of age and older, following the implementation of routine childhood pneumococcal vaccine programs in Canada.

• Immunization and vaccines

2. Who

Information in this statement is intended for provinces and territories making decisions for publicly funded, routine, immunization programs for adults who are 65 years of age and older without risk factors increasing their risk of IPD. These recommendations supplement the recent NACI recommendations on this topic that were issued for individual-level decision making in 2016.

3. How

4. Why

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This Infectious Disease Can Pose A Serious Health Risk For Those Age 65 And Older But Two Vaccines Can Offer Sound Protection

One of the leading health dangers for older adults is pneumonia. It is the most common cause of hospital admissions after childbirth. In fact, adults age 65 and older have a higher risk of death from pneumonia hospitalization than any other reason.

Pneumonia is an infection of the lungs by bacteria, viruses, or other microbes. Most cases are caused by the bacteria Streptococcus pneumoniae, Mycoplasma pneumonia, Chlamydia pneumoniae, Chlamydia psittaci, and Legionella pneumophila. A similar inflammation of the lung, called pneumonitis, can be caused by an inhaled chemical and is more common in people who have had strokes and have difficulty swallowing. A physical exam, chest x-ray, and blood test can confirm a diagnosis.

About The Pneumonia Vaccine

Pneumonia is a common enough illness, but its one that can have potentially devastating reactions. Fortunately, theres a way to prevent the serious side effects of the disease, and possibly prevent someone from getting it to begin with.

The pneumonia vaccine is a safe way to prevent most cases, and effectively lowers the chances of catching the disease entirely. People who do get pneumonia after getting the pneumonia vaccination anyway will have a much milder case of the disease if they do happen to contract it.

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Are You 65 Or Older Get Two Vaccinations Against Pneumonia

• By Gregory Curfman, MD, Assistant Professor of Medicine, Former Editor-in-Chief, Harvard Health Publishing

ARCHIVED CONTENT: As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date each article was posted or last reviewed. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician.

If you or a loved one is age 65 or older, getting vaccinated against pneumonia is a good idea so good that the Centers for Disease Control now recommends that everyone in this age group get vaccinated against pneumonia twice.

This new recommendation is based on findings from a large clinical trial called CAPiTA, which were published today in The New England Journal of Medicine.

Streptococcus pneumoniae, sometimes just called pneumococcus, is a common bacterium that can cause serious lung infections like pneumonia. It can also cause invasive infections of the bloodstream, the tissues covering the brain and spinal cord , and other organs and tissues. Older individuals are especially prone to being infected by Pneumococcus, and these infections are often deadly.

The dark spots are pneumonia-causing Streptococcus pneumoniae bacteria isolated from the blood of an infected person.

One caveat is that while PCV13 is effective in preventing pneumonia caused by S. pneumoniae, it does not prevent pneumonia caused by viruses or other bacteria.

My Doctor Didnt Tell Me About The Vaccination Is It New

The CDC began recommending adults with asthma get the pneumococcal vaccination in 2008. In 2012, the CDC started recommending adults with certain medical conditions or who take medicines like corticosteroids get the second vaccine. If your doctor hasnt mentioned the vaccine, ask about it as soon as possible.

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How Does It Compare To Other Pneumococcal Vaccines

Like Prevnar 20, Prevnar 13 is a conjugate vaccine that works in a similar way to protect you against pneumococcal disease. Pneumovax 23, on the other hand, is a polyvalent vaccine that works by producing antibodies against pneumococcal bacteria.

No vaccine is 100% effective at preventing disease, but all three pneumococcal vaccines Prevnar 13, Prevnar 20, and Pneumovax 23 are considered safe and effective for helping protect against pneumococcal disease. And this latest FDA approval demonstrates ongoing pneumococcal vaccine development, with more candidates currently in the pipeline.

Lets review some key differences between the vaccines.

How Is Pneumonia Treated

Treatment depends on the type of pneumonia you have. Most of the time, pneumonia is treated at home, but severe cases may be treated in the hospital. Antibiotics are used for bacterial pneumonia. Antibiotics may also speed recovery from mycoplasma pneumonia and some special cases. Most viral pneumonias dont have specific treatment. They usually get better on their own.

Other treatment may include eating well, increasing fluid intake, getting rest, oxygen therapy, pain medicine, fever control, and maybe cough-relief medicine if cough is severe.

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Who Should Get The Pneumonia Vaccine

The pneumonia vaccine recommendations from the CDC are for all children younger than 2 years old and all adults 65 years or older.

In other situations, children and adults should also get pneumococcal vaccines such as people with weakened immune systems, people who smoke, heavy drinkers, or people getting over surgery or a severe illness.

Side Effects Of The Pneumococcal Vaccine

Like most vaccines, the childhood and adult versions of the pneumococcal vaccine can sometimes cause mild side effects.

These include:

• redness where the injection was given
• hardness or swelling where the injection was given

There are no serious side effects listed for either the childhood or adult versions of the vaccine, apart from an extremely rare risk of a severe allergic reaction .

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Path To Improved Health

Pneumococcal vaccines can protect you against getting pneumonia, which is contagious and spreads from close, person-to-person contact. Pneumonia is an infection of the lungs and can lead to many symptoms, including:

• cough
• chest pains
• bringing up mucus when you cough

For seniors, pneumonia can be very serious and life-threatening. This is especially true if you have a chronic condition, such as diabetes or COPD. Pneumonia can also develop after youve had a case of the flu or a respiratory virus such as COVID-19. It is extremely important to stay current on flu shots each year in addition to your pneumococcal vaccines.

While PPSV23 and PCV13 do not protect against all types of pneumonia, they can make it less likely that you will experience severe and possibly life-threatening complications from the illness.

The American Academy of Family Physicians recommends that seniors who have not had either pneumococcal vaccine should get a dose of PCV13 first, and then a dose of PPSV23 6-12 months later. The vaccines cannot be given at the same time. If you have recently had a dose of PPSV23, your doctor will wait at least one year to give you PCV13.

The Different Types Of Pneumococcal Vaccine

The type of pneumococcal vaccine you’re given depends on your age and health. There are 2 types.

Pneumococcal conjugate vaccine is used to vaccinate children under 2 years old as part of the NHS vaccination schedule. It’s known by the brand name Prevenar 13.

Children at risk of pneumococcal infections can have the PPV vaccine from the age of 2 years onwards. The PPV vaccine is not very effective in children under the age of 2.

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Immunologic Basis And Host Response To Pneumococcal Vaccines

S. pneumoniae is a complex bacterium with 92 different polysaccharide capsular serotypes identified to date . The human airway uses numerous mechanisms to protect from colonization and invasive pneumococcal infection. Innate immune defenses, such as mucociliary escalator and an array of pattern recognition receptors that recognize bacterial proteins, help with the initial protection against the bacteria . The antiphagocytic bacterial capsule is considered to be the most important determinant of pneumococcal virulence and is important for colonization of the nasopharynx . Pneumococcal cell wall fragments and capsular polysaccharides are recognized by antibodies that bind and activate the complement system . All pneumococci serotypes can establish a carrier state and colonize in the human nasopharynx during the first few months of life. Children are the main reservoir, with colonization rates of up to 50%.

Pneumococcus bacteria and virulence factors including capsular polysaccharide. Immune response to polysaccharide and protein-polysaccharide conjugate vaccines. MHC=major histocompatibility complex TCR=T cell receptor. Adapted by permission from Reference .

Polysaccharide-based vaccines have been shown to result in decreased memory B-cell frequency, whereas conjugate protein-based vaccines increase serotype-specific memory B-cell responses, highlighting that these vaccines induce important T-celldependent memory responses .

Effectiveness Of The Pneumococcal Vaccine

Children respond very well to the pneumococcal vaccine.

The introduction of this vaccine into the NHS childhood vaccination schedule has resulted in a large reduction in pneumococcal disease.

The pneumococcal vaccine given to older children and adults is thought to be around 50 to 70% effective at preventing pneumococcal disease.

Both types of pneumococcal vaccine are inactivated or “killed” vaccines and do not contain any live organisms. They cannot cause the infections they protect against.

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When To Get The Vaccine

Thereâs no such thing as pneumonia season, like flu season. If you and your doctor decide that you need to have a pneumonia vaccine, you can get it done at any time of the year. If itâs flu season, you can even get a pneumonia vaccine at the same time that you get a flu vaccine, as long as you receive each shot in a different arm.

Messenger Rna Vaccinesalso Called Mrna Vaccines

Researchers have been studying and working with mRNA vaccines for decades and this technology was used to make some of the COVID-19 vaccines. mRNA vaccines make proteins in order to trigger an immune response. mRNA vaccines have several benefits compared to other types of vaccines, including shorter manufacturing times and, because they do not contain a live virus, no risk of causing disease in the person getting vaccinated.

mRNA vaccines are used to protect against:

• COVID-19

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Whats The Difference Between Pcv13 And Ppsv23

• Both vaccines help prevent pneumococcal complications like bacteremia and meningitis.
• Youll need more than one pneumonia shot during your lifetime. A 2016 study found that, if youre over 64, receiving both the PCV13 shot and the PPSV23 shot provide the best protection against all the strains of bacteria that cause pneumonia.
• Dont get the shots too close together. Youll need to wait about a year in between each shot.
• Check with your doctor to make sure youre not allergic to any of the ingredients used to make these vaccines before getting either shot.

• a vaccine made with diphtheria toxoid
• another version of the shot called PCV7
• any previous injections of a pneumonia shot

• are allergic to any ingredients in the shot
• have had severe allergies to a PPSV23 shot in the past
• are very sick

Subunit Recombinant Polysaccharide And Conjugate Vaccines

Subunit, recombinant, polysaccharide, and conjugate vaccines use specific pieces of the germlike its protein, sugar, or capsid .

Because these vaccines use only specific pieces of the germ, they give a very strong immune response thats targeted to key parts of the germ. They can also be used on almost everyone who needs them, including people with weakened immune systems and long-term health problems.

One limitation of these vaccines is that you may need booster shots to get ongoing protection against diseases.

These vaccines are used to protect against:

• Shingles

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